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EPA classifies it as in groupB2 and the ACGIH assigns it an A3 animal carcinogenclassification. The weakness progresses slowlyover years, and it is associated with worsening atrophyof the weak muscles. months, he also complains of loss of about 5 kg body weight,weakness, malaise, occasional fever and night sweating. This is a standard curved disposable scalpelblade where both edges of the curve are sharpened

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The Centre forEvidence-based Medicine (CEBM, 2009) in the United Kingdom employs differing evi-dentiary rating criteria depending on whether the evidence is to be used to guide diagnosis,treatment, prognosis, or the efficiency of service delivery.

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As this is only anapproximation, the categorisation was considered necessary to avoid having acontinuous marker that appears to be measured precisely, when this is not thecase.